7 DRUG INTERACTIONS

5.6 Adverse Reactions with the Concomitant Use of Ritonavir
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How should this medicine be used?
Utilisation dans l'hypertension artérielle pulmonaire

The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS. It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are not all the possible side effects of SILDENAFIL CITRATE TABLETS.

5.6 Adverse Reactions with the Concomitant Use of Ritonavir

SILDENAFIL CITRATE TABLETS can be taken with or without food. If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away. What are the possible side effects of SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause serious side effects.

What should I do if I accidentally use too much sildenafil?

an erection that will not go away (priapism). sudden vision loss in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss. Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes. If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS?

Drug/Class	Interaction Effect	Clinical Significance	Recommendation
Nitrates	Severe hypotension	Contraindicated	Avoid concomitant use
Alpha-blockers	Additive blood pressure lowering	Hypotension risk	Monitor blood pressure closely
CYP3A4 inhibitors	Increased sildenafil levels	Increased side effects	Dose adjustment may be necessary
Alcohol	Enhanced hypotensive effects	Increased dizziness risk	Use with caution

Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C).

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Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS.

Do not chew or break the tablet; swallow it whole.
Avoid taking sildenafil with larger doses of alcohol.
Regular exercise and a healthy diet can improve erectile function.
Do not share your medication with others.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet sildenafil generic summarizes the most important information about SILDENAFIL CITRATE TABLETS.

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Not all possible drug interactions are listed here. Store sildenafil tablets and oral film at room temperature, between 20°C and 25°C (68°F and 77°F). Store sildenafil reconstituted oral suspension below 30°C (86°F) or in a refrigerator between 2°C to 8°C (36°F to 46°F). Throw away the reconstituted oral suspension after 60 days. Active ingredient: sildenafil citrateInactive ingredients: dextrose and water for injection.

Dosage for erectile dysfunction (ED)

Contains no ingredients made from gluten-containing grain (eg, wheat, barley, or rye). Revatio is distributed by Pfizer Labs, Division of Pfizer Inc., NY, NY 10017. Viagra is distributed by Pfizer Labs, Division of Pfizer Inc., NY, NY 10017. It is distributed by: IBSA Pharma Inc, Parsippany, NJ 07054 USA. Cialis vs Viagra - What's the difference between them?

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Do you know these 11 amazing facts about Viagra? Is generic Viagra available in the U.S.? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. SILDENAFIL CITRATE- sildenafil citrate tablet, film coated Greenstone sildenafil 50mg tablet LLC What is the most important information I should know about SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS?

Parameter	Value	Unit	Description
Tmax	30-120	minutes	Time to peak plasma concentration
Half-life	3-5	hours	Time for plasma concentration to halve
Bioavailability	~40	%	Amount absorbed unchanged
Protein Binding	96	%	Extent bound to plasma proteins

This Patient Information has been approved by the U.S. Food and Drug Administration. This product's label may have been updated. For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc.

How should this medicine be used?

What should I tell my healthcare provider before taking SILDENAFIL CITRATE TABLETS? Before you take SILDENAFIL CITRATE TABLETS, tell your healthcare provider if you: have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve or heart failure have had heart surgery within the last 6 months have low blood pressure, or high blood pressure that is not controlled have had an erection that lasted for more than 4 hours have problems with your blood cells such as sickle cell anemia, multiple myeloma, or leukemia have retinitis pigmentosa, a rare genetic (runs in families) eye disease have ever had severe vision loss, including an eye problem called non-arteritic anterior ischemic optic neuropathy (NAION) have kidney problems or are having kidney dialysis Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SILDENAFIL CITRATE TABLETS may affect the way other medicines work, and other medicines may affect the way SILDENAFIL CITRATE TABLETS works causing side effects. Especially tell your healthcare provider if you take any of the following: medicines called nitrates (see "What is the most important information I should know about SILDENAFIL CITRATE TABLETS?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure.

Sildenafil Tablets or Oral Suspension for PAH

In some patients, the use of SILDENAFIL CITRATE TABLETS with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oral antifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure SILDENAFIL CITRATE TABLETS contains sildenafil, which is the same medicine found in another drug called SILDENAFIL TABLETS. SILDENAFIL TABLETS is used to treat a rare disease called pulmonary arterial hypertension (PAH). SILDENAFIL CITRATE TABLETS should not be used with SILDENAFIL TABLETS or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

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How should I take SILDENAFIL CITRATE TABLETS? Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. You may take SILDENAFIL CITRATE TABLETS between 30 sildenafil pills minutes to 4 hours before sexual activity if needed. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products.

Sildenafil was originally developed for hypertension and angina.
It was repurposed for erectile dysfunction after unintended effects were observed.
The medication is marketed under various brand names like Viagra.
Generic sildenafil citrate became available after patent expiration.

All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Sildenafil is an effective treatment for erectile dysfunction. It contains the same active ingredient as branded alternatives. Sildenafil works by encouraging more blood to flow to the penis, ensuring a strong erection when you need one.

Sildenafil is sometimes misused for recreational purposes.
Misuse can lead to serious health risks, including cardiovascular events.
Never take medication not prescribed specifically for you.
Use only under the guidance of a qualified healthcare professional.

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Utilisation dans l'hypertension artérielle pulmonaire

Do not take SILDENAFIL CITRATE TABLETS if you take any other medicines called "nitrates." Nitrates are used to treat chest pain (angina). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke. Do not take SILDENAFIL CITRATE TABLETS if you take medicines called guanylate cyclase stimulators which include: Riociguat (Adempas®) a medicine that treats pulmonary arterial hypertension and chronic-thromboembolic pulmonary hypertension. Tell all your healthcare providers that you take SILDENAFIL CITRATE TABLETS. If you need emergency medical care for a heart problem, it will be important for your healthcare provider to know when you last took SILDENAFIL CITRATE TABLETS.

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Ask your doctor if your heart is healthy enough to handle the extra strain of having sex. SILDENAFIL CITRATE TABLETS does not protect you or your partner from getting sexually transmitted diseases, including HIV—the virus that causes AIDS. SILDENAFIL CITRATE TABLETS is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine. SILDENAFIL CITRATE TABLETS helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

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SILDENAFIL CITRATE TABLETS is not for use in women or children. It is not known if SILDENAFIL CITRATE TABLETS is safe and effective in women or children under 18 years of age. Who should not take SILDENAFIL CITRATE TABLETS? Do not take SILDENAFIL CITRATE TABLETS if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in SILDENAFIL CITRATE TABLETS and REVATIO, or any of the ingredients in SILDENAFIL CITRATE TABLETS. See the end of this leaflet for a complete list of ingredients in SILDENAFIL CITRATE TABLETS.