A Guide to Prescription Treatments for Low Desire

Your DHEA levels are highest when you’re a young adult, then they slowly decrease as you age. Yes, especially in perimenopausal and postmenopausal women. In a 2017 literature review, DHEA seemed to help increase libido and arousal in women. It also made sex less painful and more pleasurable. DHEA also seemed to be linked to more frequent sexual activity and orgasms. DHEA can interfere with many common medications, especially psychiatric medications. At high doses, it’s linked to an increased risk of breast cancer and ovarian cancer. DHEA seems to be helpful for women before, during, and after menopause. But check with a healthcare professional to make sure DHEA is a safe option for you.

How FDA decisions shape access

But you shouldn’t take it during pregnancy or while nursing. Yes — especially if you’re in your 40s or older. Red clover may help with vaginal health, libido, and sexual function. Dehydroepiandrosterone (DHEA) is a hormone that your body naturally makes. It’s used to make other hormones that are important to your sex life, like testosterone and estrogen. Ashwagandha is an herb that’s used frequently in Ayurvedic medicine.

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It’s often used for reducing stress, anxiety, and inflammation.

Episode Transcript

Many different things can cause low libido, including: Hormonal changes, including changes from pregnancy or menopause Hormonal changes, including changes from pregnancy or menopause Over-the-counter (OTC) supplements are the first choice for many women who want to make a change in their sex life. But you may be wondering about how effective and safe they are. Let’s take a closer look at what the research says about eight natural supplements that have the most evidence to support them. As always, before starting any supplement, it’s important to consult with a trusted healthcare professional. Amino acids are building blocks that your body uses to make proteins.

Professional resources

Your body usually can make all the L-arginine it needs. But you can also get it by eating meat and fish, dairy, vegetables, and whole grains. Foods that are especially rich in L-arginine include: L-arginine provides the raw material your body needs to make nitric oxide, a molecule that opens your blood vessels. Nitric oxide makes it easier for blood to flow to your genitals. Good blood flow is important for sexual arousal and orgasm.

A note about sex and gender

It can also help your vagina stay nourished and healthy. There’s some evidence that L-arginine can improve libido, decrease vaginal dryness, and increase clitoral sensation. But L-arginine has mostly been studied as a combination supplement containing more than one ingredient (like ArginMax). Because of this, it’s not clear whether the positive effects seen in research studies are because of L-arginine, or L-arginine in combination with other ingredients. L-arginine taken as a supplement is potentially safe for many people, but it can have side effects, such as: It’s important to note that L-arginine may make herpes worse. It can be taken as a pill supplement or added to food and tea. According to the Nutritional Medicine Institute, there’s not much evidence on whether ashwagandha helps with sexual problems in women. But in some small studies, ashwagandha did improve lubrication, sexual arousal, and sexual satisfaction. Ashwagandha is generally safe to use in food and tea.

Improving Arousal

Yes, there’s evidence that red clover can support vaginal health in menopausal women, and reduce vaginal dryness and pain during sex. In a small study of women over age 40, taking red clover helped with vaginal dryness, low libido, and pain during sex. Red clover may also help with hot flashes, high cholesterol, and osteoporosis. But the evidence to support these claims hasn’t been consistent. According to the NIH, people have taken red clover for up to 3 years in research studies without any safety concerns. But keep in mind that it can interfere with other medications.

The Clinically Proven Treatment for Low Sexual Desire

Ginseng is a medicinal plant traditionally used to reduce stress, improve energy levels, and increase blood circulation. Like L-arginine, ginseng may encourage blood flow to your genitals, which might improve arousal, orgasm, and vaginal health. There are many different types of ginseng. Sexual health studies often focus on Korean red ginseng (KRG), which is a type of Asian ginseng. Ginseng may work for women experiencing symptoms of menopause.

Effects on sexual dysfunction

One review of research showed that KRG improved sexual arousal in menopausal women. In another study, menopausal women taking ginseng had better sexual function and improved menopause symptoms and quality of life. What’s not known is whether KRG can improve sexual function in premenopausal women. A 2015 study suggested that both placebo and KRG led to improved sexual function. So more research is needed to understand how ginseng affects premenopausal women.

IN CLINICAL TRIALS1, WOMEN ON ADDYI EXPERIENCED:

Ginseng is generally safe for most people in the short term (up to 6 months). But its long-term safety isn’t clear, according to the National Institutes of Health (NIH). Yes, especially if you’re going through menopause. There’s good evidence that KRG may help with menopause symptoms — including sexual problems. Maca is a root vegetable native to Peru. And it can cause side effects like nausea, fatigue, and headache. There hasn’t been a lot of research on ashwagandha and sexual problems in women.

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But keep in mind: It does seem to help with stress and anxiety. So if these are affecting your sex life, ashwagandha could be a good choice for you.

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Puncturevine (Tribulus terrestris) is a plant traditionally used to improve sexual function in men. It may work by increasing blood levels of testosterone — a hormone that’s related to libido, arousal, and orgasm in both men and women. Overall, the evidence is too limited to say for sure whether puncturevine helps support sexual wellness in women — especially since there haven’t been many well-designed trials yet.

Medication Class	Possible Interaction	Effect	Advice
Blood Thinners	Increased bleeding risk	Bleeding complications	Consult doctor before use
Antihypertensives	Blood pressure lowering effects	Possible blood pressure drops	Monitor BP regularly
Antidepressants	Reduced libido, serotonin syndrome possible	Reduced effectiveness of tablets	Discuss alternatives with doctor
Hormonal contraceptives	Altered effectiveness	Potential decrease in efficacy	Use additional contraceptive methods
Other herbal supplements	Excessive blood flow or side effects	Increased adverse effects	Always inform healthcare provider

In one small study of 60 women, taking puncturevine for a month improved: But in several other studies, it didn’t work better than placebo treatment. Puncturevine may have some risks, including unwanted hormonal changes. It can also potentially interact with many medications and cause stomach upset.

Trend Aspect	Description	Impact	Predicted Growth	Notable Brands
Natural ingredients	Rise in herbal and organic formulations	Increased demand for natural products	12% annually	FemVibe, Horny Goat Weed brands
Custom formulations	Personalized supplements based on individual needs	Growing consumer independence	9% annually	CustomBlend, tailored options
Online sales growth	More brands selling exclusively online	Greater accessibility	20% increase	Direct-to-consumer brands
Clinical research	More studies validating efficacy and safety	Increased consumer confidence	Steady growth	Major supplement companies
Integration with wellness apps	Apps track use and effects, provide advice	Health monitoring and guidance	15% growth	Wellness tech companies

There hasn’t been a lot of research on puncturevine and sexual health.

9. Probiotics

Possibly, especially if you’re going through menopause, or if an antidepressant causes you to have low libido. Keep in mind that it may be safer to add cooked maca to food, rather than taking it as a higher-dose capsule. Red clover (Trifolium pratense) is a plant rich in phytoestrogens, plant chemicals that act like estrogen in your body. Estrogen is a hormone that has many jobs, including keeping your vaginal tissues healthy. Estrogen also plays a role in libido and sexual arousal. And in most of the research, puncturevine didn’t seem to work very well. Probiotics are live microorganisms — like bacteria and yeast — that may have health benefits when you eat them or take them as supplements.

4. Maca

It’s traditionally used to help with infertility, boost libido, and balance hormone levels. Researchers don’t know exactly how it works. It may fildena ct have mild estrogen-like effects in the body. And it may be an “adaptogen” (an herb that helps your body respond to stress). Maca can be prepared as a food, either baked or roasted.

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It’s also available as a powder that can be mixed into smoothies or other recipes. In some cultures, maca is prepared as a fermented drink. But most of the published research on maca has been on its effects in men. Only a few studies have looked at maca and women’s sexual health. So far, there’s some evidence that maca might be helpful for sexual function during menopause.

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Maca may also help with the sexual side effects that antidepressant medications can cause. Maca seems to be safe when eaten as a food (up to 3 g daily). It may be slightly riskier if taken in larger quantities as a pill. Note that raw maca should be cooked before consuming. Try to avoid taking maca at night because it can disrupt sleep. You can get them from fermented foods like yogurt and kimchi, or from supplements. Most people take probiotics to support gut health. But they may also help support sexual health.

📝 Appendix and Notes

It can also interact with many medications. Possibly, especially if you take it as part of a combination supplement. If you’re interested in increasing your L-arginine intake, you can also consider adding L-arginine-rich foods to your diet. It’s also sometimes called vitex, chaste tree, or monk’s pepper. Chasteberry may affect hormone production and activity.

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This includes progesterone and estrogen — two hormones that are important for sexual health. In at least one study, chasteberry improved sexual function in postmenopausal women. And it may address menopause-related pain and discomfort during sex. There’s also evidence that chasteberry may help with premenstrual syndrome (PMS). This could be useful for women who have PMS-related sexual problems.

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But some people experience mild side effects, like an upset stomach, headache, and itching. It’s also not clear whether chasteberry is safe for people with hormone-sensitive conditions (like certain cancers). Be aware that chasteberry can interact with several medications, like birth control pills and antipsychotics. Possibly, especially if your sexual problems seem to be linked to menopause or PMS. But first be sure to check with a trusted healthcare professional about whether chasteberry is safe for you to try. Some research suggests that probiotic supplements may improve sexual function in women — especially those taking antidepressants.

Country/Region	Regulatory Body	Regulation Level	Requirements	Notable Restrictions
USA	FDA	Strict	Must be approved, safe ingredients	Ban on unapproved claims
EU	EMA, national agencies	Moderately strict	Clinical trials, labeling	Ingredient restrictions
Australia	TGA	Strict	Safety testing, registration	Claims verification
China	CNCA	Varies	Sometimes less regulated	Quality standards adherence
Russia	Rospotrebnadzor	Moderate	Certification required	Ingredient testing mandated

In one small study, women who took probiotics for 8 weeks reported less depression and better sexual function compared to those who didn’t. There’s some evidence that gut bacteria can affect hormone levels, which may influence sexual desire.

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But it’s not clear which probiotic strains work best — or what dose is most helpful. For most healthy people, probiotics are considered safe. Mild side effects can include gas or bloating. People with weakened immune systems should talk with a healthcare professional before using probiotics.

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