Dapoxetine tablets

If you are a man between the ages of 18 and 64, have had repeated experiences of ejaculating within 2 minutes of penetration over the last 6 months, and this is causing you distress personally or within your relationship, then Priligy may be suitable for you.

Full evidence summary

Unlike the SSRI medicines used buy cheap dapoxetine to treat depression, it is short-acting and works more quickly, so you only take it when it is needed. Priligy is suitable for men between the ages of 18 to 64 who are experiencing PE. It is available in strengths of 30mg and 60mg tablets, you start on a 30mg dose, increasing to 60mg only if your doctor thinks that it is appropriate for you. PE can mean different things to different men, so our doctors would need to understand how this affects you before deciding if it is suitable for you. Priligy has been shown to improve sexual satisfaction in men who have PE, helping you to last up to 3 times longer1. Our doctors will help you to understand if what you are experiencing is PE and whether treatment with Priligy is appropriate for you.

Parameter	Guideline
Recommended Dose	30 mg to start; possible increase to 60 mg if needed
Timing Before Sex	1 to 3 hours prior
Frequency of Use	No more than once per day
Consumption with Food	Usually taken with or without food, consistency advised
Alcohol Interaction	Avoid alcohol; increases side effects
Precautions	Not suitable for certain health conditions, consult doctor

Priligy should be taken between 1 to 3 hours before you are expecting sexual activity.

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The tablet should be swallowed whole with a full glass of water, with or without food.

Efficacy Assessments

Corona G, Rastrelli G, Limoncin E, Sforza A, Jannini EA, Maggi M. Interplay between premature ejaculation and erectile dysfunction: a systematic review and meta-analysis. Uckert S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P. Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate. Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors.

Priligy side effects

Comparative effectiveness and safety of oral phosphodiesterase type 5 inhibitors for erectile dysfunction: a systematic review and network meta-analysis. The authors would like to thank Neutec Ar-Ge San & Tic AS Clinical Research Department for their cooperation. This study has been sponsored by Neutec Ar-Ge San & Tic AS (Turkey). The authors declare that they have no conflict of interest. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Related Salt

Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction—DAP-SPEED Study. What Is the Role of Ejaculation Latency in the Diagnosis of Premature Ejaculation and Does the Ejaculation Latency Threshold Matter? Conservative Non-surgical Options for Erectile Dysfunction Current Urology Reports (2023) The role of tyrosine hydroxylase within dapoxetine-assisted therapy against premature ejaculation Molecular Biology Reports (2023) Current and emerging treatment options for premature ejaculation Nature Reviews Urology (2022) Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity Nature Reviews Urology (2021) Priligy is a prescription treatment if you are male and experiencing premature ejaculation (PE), which can affect you at any age. It contains the active ingredient Dapoxetine, a type of medicine called an SSRI, originally developed to treat depression but then found to be effective for treating PE. Priligy increases the time it takes to ejaculate, can improve control over ejaculation and therefore reduces the frustration and anxiety you feel when experiencing PE. Do not drink alcohol whilst taking Priligy tablets.You should never take more than one dose of the tablet each day, or within a 24-hour period. You must answer the consultation questions honestly and fully so our doctors can ensure that treatment is appropriate for you and we can give you the best advice. Priligy is not suitable if you have certain health conditions including, heart conditions, unstable epilepsy or a history of fainting or severe depression. It also cannot be taken alongside some prescription and non-prescription medicines.

• Dapoxetine's impact on libido is generally minimal, focusing on ejaculation control.
• Use of dapoxetine should be part of an overall sexual health plan.
• Adherence to prescribed doses maximizes benefits and minimizes risks.
• Side effects usually resolve within a few hours or days.
• Avoid driving or operating heavy machinery after taking dapoxetine if drowsiness occurs.
• Regular discussions with your healthcare provider improve treatment outcomes.

Our doctors can advise you fully if treatment is suitable for you.

Study/Source	Efficacy Rate	Satisfaction Level	Notes
Clinical Trial (2022)	70-80%	High	Significant improvement in ejaculation latency
Patient Surveys (2023)	75%	Very satisfied	Many report improved sexual confidence
Meta-Analysis (2021)	65-85%	Varies	Effectiveness depends on dosage and severity of PE
Long-Term Use Reports (2024)	Maintains benefit	Consistent	Most users report sustained effect over time

Like all medicines, Priligy can cause side effects, although not everybody gets them.

Premature Ejaculation: Common, Treatable, and Often Under-Discussed

An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the Second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation. Patrick DL, Althof SE, Pryor JL, Rosen R, Rowland DL, Ho KF, et al. Premature ejaculation: an observational study of men and their partners. An update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE). Efficacy of dapoxetine for the treatment of premature ejaculation: a meta-analysis of randomized clinical trials on intravaginal ejaculatory latency time, patient-reported outcomes, and adverse events.

Data extraction

Park HJ, Park NC, Kim TN, Baek SR, Lee KM, Choe S. Discontinuation of dapoxetine treatment in patients with premature ejaculation: a 2-year prospective observational study. Mondaini N, Fusco F, Cai T, Benemei S, Mirone V, Bartoletti R. Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a “Waterloo”. Premature ejaculation and erectile dysfunction prevalence and attitudes in the Asia-Pacific region.

Drug-related adverse effects (AEs)

AUA guideline on the pharmacologic management of premature ejaculation. EAU guidelines on erectile dysfunction, premature ejaculation, penile curvature and priapism. Arnhem, The Netherlands: EAU Guidelines Office; 2018. Efficacy of phosphodiesterase-5 inhibitor in men with premature ejaculation: a new systematic review and meta-analysis. Men C, Yu L, Yuan H, Cui Y. Stop taking Priligy and contact our doctors straight away if: You faint or feel light-headed when you stand up You notice any changes in your mood You have any thoughts of suicide or harming yourself.

• Dapoxetine is a quick-acting medication designed for on-demand use before sex.
• It is effective in delaying ejaculation and increasing satisfaction.
• The medication is generally safe when used as directed under medical supervision.
• It is important to consider psychological factors alongside medication treatment.
• Dapoxetine may be combined with counseling or therapy for better results.
• Discontinuing dapoxetine should be discussed with your doctor first.

If you notice any of the above, stop taking Priligy and contact our doctors straight away, or seek medical attention if symptoms are severe.

• Differential diagnosis: rule out erectile dysfunction, hormonal issues.
• Physical exam is part of assessment but often normal in PE.
• Validated questionnaires (e.g., PEDT) aid in diagnosis and monitoring.
• Treatment goal: satisfactory sexual experience for both partners.
• Dapoxetine addresses the biological, not solely psychological, aspect.
• May reduce performance anxiety secondary to PE.
• Prescribing guidelines emphasize starting at lowest effective dose.
• Long-term data on intermittent use over years is limited.

This medicine can make you faint or make your blood pressure drop when you stand up.

Aspect	Details
Drug Class	Selective Serotonin Reuptake Inhibitor (SSRI)
Mechanism of Action	Increases serotonin levels in the nervous system, delaying ejaculation
Half-Life	Approximately 19 hours
Metabolism	Liver (via CYP enzymes)
Excretion	Primarily in urine
Interaction Potential	May interact with other serotonergic drugs

To help lower the chance of this happening: Take this medicine with at least one full glass of water Do not take this medicine if you are dehydrated (you do not have enough water in your body).

• Some men may experience mood changes or irritability with dapoxetine.
• Alcohol use can increase the risk of side effects when taking dapoxetine.
• Dapoxetine is not approved for use in women or children.
• Store dapoxetine in a cool, dry place away from children.
• Always report any unusual or severe side effects to your doctor.
• It is important to get a medical assessment before starting dapoxetine.

This can happen if:– You have not had anything to drink in the past 4 to 6 hours– You have been sweating for a long time– You have an illness where you have a high temperature, diarrhoea or being sick If you feel like you might faint (such as feeling sick, feeling dizzy, light-headed, confused, sweaty or an abnormal heartbeat), or feel light-headed when you stand up, then you should immediately lie down so your head is lower than the rest of your body or sit down with your head between your knees until you feel better. This will stop you from falling and hurting yourself if you do faint Do not stand up quickly after you have been sitting or lying down for a long time Do not drive or use any tools or machines if you feel faint when taking this medicine Tell our doctors if you faint when taking this medicine.

How Dapoxetine Works

Other non-medical self-help techniques in combination with treatment may give you the best results. Priligy is a type of medicine known as selective serotonin reuptake inhibitor (SSRI). It exerts its action by helping to maintain the body’s natural serotonin levels. Serotonin is a natural hormone in our bodies which is responsible for many activities, including helping to regulate our mood and wellbeing. The involvement of serotonin in sexual arousal and ejaculation is not clearly understood but is believed to have a role because of the effectiveness of treatment with SSRIs such as Priligy. Very common side effects: may affect more than 1 in 10 men Common side effects: may affect up to 1 in 10 men Feeling numb or having ‘pins and needles’ Uncommon side effects: may affect up to 1 in 100 men Fainting or feeling dizzy upon standing (see advice above) Change in mood, feeling overly excited or feelings of paranoia Feeling confused, disoriented or unable to think clearly Slow or irregular heartbeat or increase in heart rate Loss of sex drive, problems reaching orgasm Vision problems, eye pain or dilated pupill Rare side effects: may affect up to 1 in 1,000 men If you get any side effects, contact our doctors, this includes any possible side effects that are not listed here. Introduction: Men with comorbid erectile dysfunction (ED) and premature ejaculation (PE) may be concomitantly prescribed a phosphodiesterase type 5 (PDE5) inhibitor and dapoxetine.

Medicine Leaflet Review Manager – Contractor, Pharmacist

Efficacy and safety of phosphodiesterase type 5 inhibitors on primary premature ejaculation in men receiving selective serotonin reuptake inhibitors therapy: a systematic review and meta-analysis. Asimakopoulos AD, Miano R, Finazzi Agro E, Vespasiani G, Spera E. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time. The comparison of premature ejaculation assessment questionnaires and their sensitivity for the four premature ejaculation syndromes: results from the Turkish society of andrology sexual health survey.

How to take Priligy

Patrick DL, Giuliano F, Ho KF, Gagnon DD, McNulty P, Rothman M. The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of sildenafil and dapoxetine erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation.

Priligy alternatives

A tutorial on pilot studies: the what, why and how. Advances in understanding and treating premature ejaculation. Acceptance of and discontinuation rate from paroxetine treatment in patients with lifelong premature ejaculation. McMahon CG, Porst H. Oral agents for the treatment of premature ejaculation: review of efficacy and safety in the context of the recent International Society for Sexual Medicine criteria for lifelong premature ejaculation.