Understanding Chewable Sildenafil Formulations
To the limited extent that they do collaterally inhibit other PDE families, they can produce different side effects corresponding to those PDE families and what their normal jobs are in our bodies.
Tadalafil (the active ingredient in Cialis)
We’ll break it all down so that you can proceed in confidence or explore alternative treatment options. BlueChew entered the landscape as a unique company — the first to provide chewable prescription treatments for ED online. Initially, this meant compounded versions of the active ingredients in Viagra and Cialis, which are sildenafil and tadalafil, respectively. But later, BlueChew introduced a third option: chewable vardenafil, the active ingredient in Levitra. BlueChew offers ED prescriptions through an online portal, allowing you to have medication delivered straight to your door wherever you live in the United States (as long as that isn’t North Dakota), without any physical doctor’s visit or trip to a pharmacy.
Recreational use
While it may have been the first, BlueChew is no longer the only company to do all of this. It’s among a sildenafil 5mg for sale widening group of providers offering compounded forms of well-studied prescription ED medications. These compounded drugs have the same therapeutic potency as traditional, brand-name pills. Dosages do vary from company to company, which is something we’ll outline later in this guide since it can affect the likelihood of side effects. The company recently introduced a daily version of its tadalafil chew.
Before taking medication for ED
(Previously, only an as-needed version of tadalafil was available.) The main difference between daily and as-needed tadalafil prescriptions tends to be dosage, though BlueChew’s daily chew does include supportive supplemental ingredients. Some of these, such as vitamin D and folic acid, are even present at levels that studies indicate could be beneficial for men trying to address ED.37 38 Only a medical professional — like the kind affiliated with BlueChew or its competitors, or a doctor you’d see in a traditional office — can determine if you’re a safe and suitable candidate for these medications. If you are, it means the medical professional has reviewed pertinent details about your medical history, health, and current medications and concluded that using one of these medications will likely help address your ED symptoms without posing a serious risk to your health. But if you are approved, it does not guarantee you’ll experience no side effects. In fact, side effects are not uncommon. And while all three of the medications share a small set of common potential side effects — headache, nasal congestion, and dyspepsia —
- Sildenafil is part of a class of drugs called phosphodiesterase inhibitors.
- Chewing sildenafil tablets can potentially cause burns or irritation.
- Always follow your doctor’s instructions for sildenafil dosage.
- Sildenafil may cause a drop in blood pressure in some users.
- Use sildenafil only under medical supervision.
- Do not use sildenafil if you are taking certain alpha-blockers.
- Chewing sildenafil is not a recommended administration route.
- Keep track of sexual activity and medication effects.
- Regular check-ups are advised when using sildenafil long-term.
most adverse side effects happen because of the medications inhibiting other PDE families aside from PDE5.35 Sildenafil and vardenafil collaterally inhibit PDE1 and PDE6.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 100mg | 20 Pills | 45.58€ 43.41€ | |
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Generic | 100mg | 90 + 6 Pills | 129.02€ 122.88€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ |
Tadalafil, meanwhile, doesn’t cause that kind of collateral effect, but it does collaterally inhibit PDE11.6 This provides some explanation for why these medications differ in the side effects they're most likely to cause.
- Sildenafil improves erectile function by enhancing blood flow.
- Chewing sildenafil tablets is not an approved method of administration.
- Use sildenafil only as prescribed by your doctor.
- Do not double-dose if an effect is not immediate.
- Be aware of possible side effects like flushing or stomach upset.
- Sildenafil should not be taken with certain heart medications.
- Store sildenafil in a cool, dry place away from children.
- Combining sildenafil with recreational drugs can be dangerous.
- Seek medical attention for prolonged erections or severe side effects.
As the active ingredient in Viagra, sildenafil is probably the most common and certainly the longest-studied ED medication on the market today.
- Sildenafil can cause temporary vision changes in some users.
- Chewing sildenafil isn't recommended by healthcare professionals.
- Sildenafil’s effects typically last around 4-6 hours.
- Do not take sildenafil more than once in a 24-hour period.
- Always read the leaflet included with sildenafil medication.
- Be aware that chewing sildenafil may impact drug stability.
- Use sildenafil only as prescribed by a healthcare professional.
- Be mindful of potential interactions with alcohol or other drugs.
- Monitor for adverse reactions after taking sildenafil.
It’s the one that started them all, the only one introduced in the 20th century; if you’re old enough, you may remember Bob Dole as a spokesman for it following his presidential campaign in the late ‘90s.
Adverse effects
cGMP relaxes the smooth muscles in the walls of blood vessels, which is what causes them to widen — something called vasodilation.4 So, NO can promote increased blood flow. When it is released vascularly upstream from the spongy tissues of the penis, NO leads to more cGMP in those tissues, which enables the increase in blood flow and accumulation of blood there, causing an erection.5 What causes an erection to stop, meanwhile, is PDE5; when the body feels that it’s time for an erection to end, PDE5 is released to bind to the cGMP, causing smooth muscles in the blood vessels to return to normal.6 This means less blood flow to the penis, and the erection goes away. Inhibiting PDE5 is an effective way to allow many (but not all) men with ED to get erections strong enough for the sexual activity they want. And the reason these treatments don’t cause spontaneous erections is that arousal is still necessary for the brain to signal to the cavernous nerve (a nerve in the penis) to release NO there.6 (Remember, NO has the aforementioned effects vascularly downstream of where it is released.) None of the PDE5 medications that BlueChew offers are completely selective for PDE5. In other words, they can inhibit other families of PDE as well. Like vardenafil, sildenafil is an as-needed medication.
| Parameter | Data | Explanation |
|---|---|---|
| Absorption Time | 15-30 min | Faster than standard tablets |
| Peak Plasma Levels | 1 hour | When maximum effect occurs |
| Half-life | 4 hours | Time for plasma concentration to reduce by half |
| Metabolism | Liver (CYP3A4 enzyme) | Main pathway for breakdown |
You’ll take it 30-60 minutes before sexual activity may occur, and after that waiting period, the medication will be effective for a period of 4-6 hours.
Detection in biological fluids
Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". Archived from the original on 23 April 2011. ^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013.
The Fast Facts
Archived from the original on 22 August 2009. Archived from the original on 25 June 2007. "Viagra from the pharmacist: insight from reclassification in New Zealand". Archived from the original on 17 May 2021. ^ "Generic Viagra developers queue up, but may have to wait".
Is BlueChew covered by insurance?
Archived from the original on 28 December 2021. ^ "Approved Viagra copies flood drugstores in Korea". ^ "Viagra prescriptions almost triple in a decade". Archived from the original on 1 July 2024. ^ "MHRA reclassifies Viagra Connect tablets to a Pharmacy medicine". On the one hand, the fact that it’s the longest-studied ED medication can give people some peace of mind, and it’s still the first path that many prescribing doctors explore with patients.
| Year | Estimated Market Size (USD) | Growth Rate | Key Factors Influencing Market |
|---|---|---|---|
| 2023 | 200 million | 12% | Preference for fast, discreet options |
| 2024 | 224 million | 12% | Increased awareness and availability |
| 2025 | 251 million | 12% | Growing aging population and social acceptance |
On the other hand, years of research also reveal that sildenafil seems capable of causing certain side effects that a couple newer options like vardenafil and avanafil likely won’t.
See also:
Thankfully, they tend to be very mild, with few people discontinuing treatment because of them. In our surveying the landscape of available ED treatments — prescription medications, over-the-counter options like supplements, and various devices you’d use at home or in a clinical setting — none currently offer the same combination of effectiveness, safety, affordability, and convenience as the treatments BlueChew offers. To understand why BlueChew’s ED medications would cause side effects and also why those side effects would vary from drug to drug, it’s useful to know a few basic details of how the medications work. All of BlueChew’s medications are PDE5 inhibitors, a class that also includes relative newcomer avanafil (Stendra), which BlueChew does not yet offer. PDE5 stands for “phosphodiesterase type 5.” (You can see why people use the abbreviation.) Phosphodiesterases are a superfamily of enzymes that act as regulators of signals being sent within cells.
Dosage for erectile dysfunction (ED)
As the number in PDE5 would suggest, there are numerous families of phosphodiesterase that have been identified — 11, to be precise (PDE1 through PDE11) — and they all have different effects on the human body.3 Scientists further divide these families into subtypes and splice variants. As BlueChew’s medications are all PDE5 inhibitors, they all temporarily prevent PDE5 from doing what it normally would do in your body… which makes it useful to understand what PDE5 ordinarily does. You may or may not have heard of the chemical, nitric oxide (NO). Some people take dietary supplements to increase NO in their bodies, typically with goals involving exercise performance, sexual performance, or general cardiovascular health. This is because NO, vascularly downstream of where it is released in the body, causes the conversion of GTP (guanosine triphosphate) into cGMP (cyclic guanosine monophosphate). Avanafil — the active ingredient in Stendra and the newest PDE5 for ED — is a relatively costly medication offered by Hims but not BlueChew.
Chewable Tadalafil
^ "Viagra to be available without prescription in UK". Erectile dysfunction (ED) affects many people — likely a third of men.1 It becomes more common with age, yet 5% of men under 40 are unable to get an erection.2 As you explore your options for ED treatment, you’ll naturally want to know whether treatments are effective, safe, and affordable. These bedrock considerations overwhelmingly shape our regard for any medical treatment. But there are layers to the subject of safety; a treatment can be generally safe while also possibly causing mild side effects in a broad group of people. And what one person considers a minor nuisance may be a deal-breaker for another.
Tips for taking Viagra
One provider of ED medications — BlueChew — has understandably attracted a lot of attention over the past several years. For some people, BlueChew’s ED medications are a non-starter — unsafe or unsuitable for underlying health reasons, as determined by a consulting medical professional. If you’re considered a good candidate for treatment, it means that you will be able to access some of the most effective, safe, and affordable ED treatments available. But that doesn’t mean you won’t experience a side effect, or maybe more than one. So, what are BlueChew’s side effects?
Key takeaways
Are they exactly the same for each treatment option? What about the likelihood of experiencing them? Because so many people have asked us for clarification about the potential side effects of BlueChew, we’ve created this comprehensive guide to shed more light on this important subject. If you’re going to begin a new medication like the ones BlueChew offers, you should definitely know what side effects you could encounter — and when those side effects should prompt you to speak to a doctor. Thankfully, BlueChew side effects are usually mild, but the likelihood and nature of possible side effects varies by medication and is affected by dose. It’s the most selective PDE5 inhibitor and less likely to cause side effects.7 Sildenafil’s most common side effects are mild and include:8 Dyspepsia (discomfort in the upper abdomen caused by stomach upset) Vision changes (such as a blue-green tint, temporarily blurred vision, or difficulty with color perception) Side effects involving vision disturbances arise due to the fact that sildenafil also collaterally inhibits PDE6.
- Sildenafil should not be used with nitrates due to dangerous interactions.
- Chewing sildenafil can lead to inconsistent blood levels.
- Overusing sildenafil can cause priapism or prolonged erections.
- Be cautious about using sildenafil if you have heart problems.
- Sildenafil may cause side effects like headaches or flushing.
- Chewing sildenafil does not improve its therapeutic effect.
- Always store sildenafil out of reach of children.
- Check with your healthcare provider if unsure about dose or form.
- Do not combine sildenafil with other ED medications without guidance.
- Important Drug Interactions with Sildenafil Citrate
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